Jan 1, 2020 · Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature. In this work, we review the different mechanisms that can be linked to monoclonal antibodies instability, the parameters, and conditions affecting their stability (protein structure and concentration, temperature, interfaces, light exposure, excipients and contaminants, and agitation) and the
Optimization of surfactant concentration in i.v. bags and vials. Due to unacceptable protein loss upon administration of the mAb formulated in histidine buffer alone, a second study (in-use stability study 2) was designed to determine whether incorporating the surfactant polysorbate 80 (PS80) into the formulation could enable the delivery of ≥90% of the dose.
The analysis of low abundance species, pH sensitive analytes or not yet well understood compound mixtures benefit from consistent and well controlled vial surfaces. The glass surface of TruView pH Control LCMS Certified Vials minimizes pH shifts away from the neutral and thus eliminates unwanted reactions and resulting ghost peaks.
Mass Spectrometry Vials. Our certified, low adsorption (LA), LC/MS vials and kits are designed to reduce surface activity while improving analytical quantitation. The QSertVial™ microsampling device contains a fused, 300 μL glass insert and is compatible with most autosamplers. Our certified center drain (CD) vials and kits feature a unique
This results in extremely low compound loss through adsorption or catalytic degradation. Our glass vials have very low reactivity, pH shift, and leaching characteristics. Extra Low Adsorption vials are a must have for MS users or when working with micromolar concentrations and/ or low sample volumes, where the surface-to-volume effects are much
Freezing the samples is a common preservation procedure. Samples that cannot be frozen or that do not need to be frozen (with nonvolatile matrix and analytes, or stable at ambient temperature) are usually stored at 0–5° C. Several conditions for sample storage are given in Table 2.4.1. Table 2.4.1.
The Chapters are further organized by sample types so that gaseous samples are first (Chapter 6) followed by liquid samples (or samples put into a liquid form) (Chapters 7-12), solid samples (Chapter 14), biological samples (nucleic acids and proteins)(Chapter 15), biological fluids/tissues (Chapter 16) and then special topics such as sample
Aug 10, 2020 · At low relative pressure (0–0.11), there is a rapid increase in water adsorption where monolayer adsorption dominates, and then a slow increase follows over the range of 0.11 to 0.32 where
The analysis of low abundance species, pH sensitive analytes or not yet well understood compound mixtures benefit from consistent and well controlled vial surfaces. The glass surface of TruView pH Control LCMS Certified Vials minimizes pH shifts away from the neutral and thus eliminates unwanted reactions and resulting ghost peaks.
Enhancing Sample Integrity with Low-Adsorption Vials for Critical and Sensitive Samples: Practical Applications and Benefits for Researchers The Horror of Sample Adsorption to Containers (Part 1) Because LC/MS is capable of detecting with high sensitivity, the samples used in LC/MS are very low in concentration.
1) The low-adsorption glass vials (LabTotal vials) inhibit the adsorption of basic compounds. 2) The low-adsorption PP vials (TORAST-H TM Bio vials) inhibit the adsorption of peptides. These low-adsorption vials are expected to help ensure the reliability of high-sensitivity analysis.
Aug 18, 2021 · Abstract This work describes lyophilization process validation and consists of two parts. Part I focuses on the process design and is described in the current paper, while part II is devoted to process qualification and continued process verification. The intent of these articles is to provide readers with recent updates on lyophilization validation in the light of community-based combined
The analysis of low abundance species, pH sensitive analytes or not yet well understood compound mixtures benefit from consistent and well controlled vial surfaces. The glass surface of TruView pH Control LCMS Certified Vials minimizes pH shifts away from the neutral and thus eliminates unwanted reactions and resulting ghost peaks.
Jun 22, 2020 · The study summarised the following glass-related factors that can directly affect sample integrity and data output [2]: Vial-to-vial reproducibility: For protocols involving longer workflows or laboratories with higher throughput, using glass vials with lower adsorption coefficients can eliminate the need for interruptions during the routine
Cronus Vials Brochure - Schmidlin Labor + Service10mm Screw Cap Vials (Wide Mouth). 12. 12x32mm. Vials. Other. Vials Champagne Vial, 1.5ml, Amber Glass Inserts for 9-425 Scre